Product name:Irinotecan hydrochloride

Synonyms:CamptothecinII;CPT-II;[1,4′-Bipiperidine]-1′-carboxylicacid,CPT-11,(S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-ylester;(4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-yl[1,4′-bipiperidine]-1′-carboxylicacidesterhydrochloride;(S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinolin-9-ylester

CAS No:3100286-90-6

Molecular formula:C33H39ClN4O6

Molecular Weight:623.15

Appearance:Pale yellow powder

Melting point 250-256°C (dec.)

Storage conditions Refrigerator

Iritecan hydrochloride is a semi synthetic derivative of water-soluble camptothecin. It is light yellow powder or light yellow crystalline powder at room temperature, and it has no odor. It is slightly soluble in water, ethanol or chloroform and insoluble in acetone. Camptothecin can be specifically combined with topoisomerase I, which induces reversible single strand breaks, which leads to the spin of DNA double strand structure; Iritecan and its active metabolite SN-38 can be combined with topoisomerase I-DNA complex, thus preventing the reconnection of single bond, thus producing cytotoxicity. This chemicalbook cytotoxicity is time dependent, and has a specific effect on phase s, and is more toxic than iritecan. It is suitable for the treatment of advanced colorectal cancer patients, combined with 5-fluorouracil and folic acid in the treatment of patients with advanced colorectal cancer who have not received chemotherapy before. As a single drug, the treatment of patients who have failed to be treated by chemotherapy with 5-fluorouracil is used. Iritecan has a wide spectrum and strong antitumor activity in vivo and in vitro research. It is important that iritecan and its metabolites are still effective for the tumor expressing multidrug resistance.