Product name:7-Ethyl-10-hydroxycamptothecin

Synonyms:7-10-hydroxycamptothecin;(4S)-4,9-Dihydroxy-4,11-diethyl-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;(4S)-4,9-Dihydroxy-4α,11-diethyl-3,4,12,14-tetrahydro-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-dione;EHCPT;7-Ethyl-10-hydroxy-CPT(Camptothecine),SN-38;10-Hydroxycamptothecinacetatesalt,99%;IrinotecanRelatedCompoundB(10mg)((S)-4,11-diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)

CAS No:86639-52-3

Molecular formula:C22H20N2O5

Molecular Weight:392.4

Appearance:Yellowish crystalline powder

Melting point 217 °C

Boiling point 810.3±65.0 °C(Predicted)

Density 1.51±0.1 g/cm3(Predicted)

Storage conditions −20°C

SN-38 (nk012) is an active metabolite of CPT-11, which inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single strand breaks. SN-38 can induce autophagy.